Neurobiological applications of small molecule screening.
نویسندگان
چکیده
2.2.1. High-Throughput Screening in vitro 1778 2.2.2. Cell-Based Screening Methods 1779 2.2.3. Tissue-Explant-Based Screens 1780 2.2.4. Organismal Model Systems 1780 2.3. Assay Detection Methods 1781 2.3.1. Spectroscopic Methods 1781 2.3.2. High-Content Screening 1781 3. Target Validation 1782 3.1. Affinity Chromatography 1782 3.2. Protein and Small Molecule Microarrays 1782 3.3. Classical Genetic Screens 1783 3.4. Transcription and Proteomic Profiling 1783 3.5. RNA Interference 1783 4. Concluding Remarks 1783 5. Acknowledgments 1783 6. References 1783
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عنوان ژورنال:
- Chemical reviews
دوره 108 5 شماره
صفحات -
تاریخ انتشار 2008